Description
Product Characteristics:
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Subcellular location: Cytoplasm, Nucleus
Synonyms: C19orf2, Chromosome 19 open reading frame 2, NNX3, PPP1R19, Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RMP_HUMAN, RNA polymerase II subunit 5 mediating protein, RNA polymerase II subunit 5-mediating protein, RPB5 mediating protein, RPB5-mediating protein, Unconventional prefoldin RPB5 interactor 1, Unconventional prefoldin RPB5 interactor, URI, URI1, prefoldin-like chaperone.
Target Information: This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]